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The emerging trend of digital twin technology and high-performance computing is creating a revolutionary paradigm shift in the coming years. For smart work zones and other integrated safety and mobility applications, the pairing of the virtual and physical world allows the analysis of data and monitoring of systems, evaluation of different improvement strategies, and future planning through advanced simulation and analytics tools. Discover how digital twin technology is transforming the interconnection between open data, drivers, roadway designers and traffic engineers. Examine the prototype of a FHWA-sponsored open data hub and open-source framework for transportation safety-focused digital twin applications.