Digital inclusion is increasingly recognized as a social driver of health. There is significant variation in screening for digital inclusion with regards to what questions are asked, how data are recorded, who conducts the screening, and how connections to resources are made. To exacerbate these challenges, few well-validated screening questions exist for use in populations that are lower income, older, or have limited English proficiency. This panel will share insights learned from initiatives to optimize the screening process for digital needs at four health systems representing geographically and socioeconomically diverse populations: an urban safety net system in San Francisco, an integrated health system in Northern California, an urban safety net system in Los Angeles, and an academic health system in Boston. Lessons learned will focus on emerging best practices on screening questions to determine who needs help; when and how to screen patients; and what kind of help is desired.