As patient access to care through digital means increases, there is a growing recognition of the need to monitor patients between visits to improve triage and provide data for clinical decision making. However, tools and interventions to facilitate such monitoring are not yet the standard of care. Monitoring tools based on electronic patient-reported outcomes (ePROs) offer a promising and scalable solution. In this panel, four presenters discuss progress in between-visit monitoring using ePROs in four medical conditions: active cancer, asthma, rheumatoid arthritis, and heart failure. The discussion will show how even though these interventions are being developed in condition-specific ways, important common elements exist. Attendees will learn emerging best practices for using ePROs to monitor patients between visits as well as key challenges.