In alignment with 2021’s “Great Resignation,” informaticians are realizing the need to reprioritize various aspects of their professional and personal lives. Career transitions, especially for women scientists, which includes informaticians, mark vital inflection points in their professional trajectories. Such inflection points can mean new, perhaps previously unforeseen opportunities in informatics careers and potential for professional growth as innovators and entrepreneurs. Biomedical and health informatics offers a professional pathway that spans and bridges industry, academia, governmental and non-governmental service, and much more. The ongoing growth of informatics and the continued pressure on technologic solutions to help solve some of the biggest challenges in healthcare, leads the field of informatics to be open to those who seek professional growth and career satisfaction. Most notably, technology is being viewed as a way to address health inequities, improve access to care, halt the unsustainable growth of healthcare costs, and improve health outcomes. With health expenditures expected to reach $6 trillion by 2027 and billions being invested into health information technology, the job market continues to grow. The Office of the National Coordinator estimated that an additional 50,000 workers would be required to meet the demand in the health information technology industry. To support this growth, there needs to be greater transparency into how to enter the field and build a successful career. This interactive workshop is designed to address the gaps that may exist in much of the academic and private sector to support professional development and career transitions for informaticians.