Different types of organizations build increasingly large amounts of knowledge assets. These organizations are responsible for the accuracy and availability of the assets they produce. Inconsistent, incomplete, outdated, and inaccessible knowledge assets contribute to operational costs and create quality and safety risks. Such costs and risks are greater when knowledge management activities are reactive and ad-hoc, lack a formal content review and maintenance process, and are not aligned with business goals and strategies. This workshop will survey basic and advanced knowledge management topics, such as definitions of knowledge, data, and metadata; the knowledge engineering lifecycle; effective governance; best practices to manage dependencies between knowledge artifacts as they evolve; and efficient processes to guarantee structural and semantic integrity of knowledge assets. The second half of the workshop will describe the experiences, challenges, lessons learned and solutions implemented of a large-scale operational commercial knowledge management program for curating medical device records.