Cultivating cross-functional influence and impact within and beyond the AMIA community is vital for biomedical and health informatics professionals. This involves leveraging the expertise and collective influence of communities of professionals to achieve professional goals that benefit the informatics field overall. However, learning to be an effective leader and influencer in professional societies like AMIA can be hindered by a lack of knowledge about the society’s structure and community and a lack of best practice examples on how to drive impactful work within and beyond the AMIA community through cross-functional leadership and change management. Moreover, the informatics is changing rapidly, with the boundaries between academia, health systems, government, and industry continuing to blur. This panel thus sets out to provide a reference guide on the topic of “How to Thrive in AMIA” to new AMIA Symposium attendees and a refresher for existing members. The panelists will also introduce best practices that help make impacts beyond the AMIA community. These included the report from the AMIA Health Informatics Careers Task Force that illustrate career pathways of early, mid-career, and experienced informaticians, the report of 2017-2022 Gender Representation from the Awards & Leadership Subcommittee on informatics workforce and leadership position counts, and interviews of cross-functional leadership from the new AMIA-ACM podcast series on how to catalyze changes in the multidisciplinary workforce. In the open discussion, we will invite attendees to share their experiences and discuss how the changing informatics landscape affects best practices in improving cross-functional visibility and leadership.