Functional status describes the lived experience of health, and understanding the factors that affect functioning is key to delivering patient-centered healthcare. Global aging and the growing prevalence of multi-morbidity and disability are making understanding functioning outside the clinic equally important to diagnosis and treatment inside the clinic. However, information on functional status has proven difficult to capture and utilize within existing information systems and informatics paradigms, leaving a space ripe for technological innovation. The AI4Function workshop series is a venue for researchers across data science and artificial intelligence, rehabilitation science, and clinical informatics to discuss new ways to collect and utilize functional status information within healthcare delivery, public health, and social well-being. Functional status is complex and multidimensional, including information on activity performance, social role participation, and environmental and personal factors that affect work, well-being, and quality of life. The AI4Function workshop series reflects both theoretical and practical aspects of this complexity, including research on tools and methods for functional measurement, methodologies for analyzing multimodal function data, and informatics-driven interventions for monitoring and optimizing functional status. The 2022 edition of the workshop will focus on fostering collaborations and identifying key challenges and directions for functional status informatics research in AMIA. The workshop will include: (1) a panel discussion on data resources for research on functional status; (2) a poster session for informatics researchers studying functional status to share recent or upcoming work; and (3) a discussion session to identify next steps for growing functional status informatics in the AMIA community.