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This panel will provide academic researchers, health informatics professionals, vendor representatives, and clinicians with pragmatic recommendations to develop and sustain cross-sector partnerships to improve digital health equity. The panel includes a primary care physician and health services researcher based in a safety-net health care setting, two digital health entrepreneurs, and a moderator with expertise at the intersection of academia and health informatics. The panelists will describe two research projects that investigate and adapt the fit of health technology for historically marginalized and minoritized populations, including why and how they initiated the projects, what they learned, and how their success may be replicated elsewhere. After participating, attendees should be better able to understand current gaps in consumer health informatics for vulnerable populations, recognize how cross-sector partnerships may be able to address some of these gaps, and formulate recommendations for developing such partnerships in pursuit of equitable digital health innovation.