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AHRQ formed the ACTS COVID-19 Evidence to Guidance to Action Collaborative in early 2020 as a learning community to help participants respond to the emerging pandemic. This Collaborative was an outgrowth of the AHRQ evidence-based Care Transformation Support (ACTS) initiative, which had spent the previous year developing a shared vision for health IT-enabled, evidence-informed care delivery and transformation, and a draft stakeholder-driven Roadmap for broadly achieving this vision. This panel will outline AHRQ’s goals and process for delivering broad value from the Collaborative and provide perspectives from three participants on how the Collaborative supported their efforts to improve care processes and outcomes for COVID-19 and beyond. After panelist presentations, the second session half will be interactive discussion with attendees (likely including other Collaborative participants) to surface opportunities to leverage efforts such as the Collaborative to accelerate care transformation within and across organizations.