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The ACTS COVID-19 Evidence to Guidance to Action Collaborative is an open learning community supported by AHRQ to help participants respond to the current pandemic. During summer 2021, the Collaborative is describing a compelling ‘art of the possible’ future vision where interoperable and computable healthcare evidence, guidance and data drive whole person care for COVID-19 and other clinical conditions. The future vision includes highly desirable but not yet widely realized patient journeys, as well as needed enhancements to the national / global healthcare knowledge ecosystem to widely realize these outstanding healthcare experiences, processes, and results. This panel will describe this future vision, steps that presenters and others are taking toward realizing it, and additional action needed. After panelist presentations, the second session half of the panel will be interactive discussion with attendees to surface additional opportunities for collaboration and other steps to refine and fully realize the shared future vision.