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COVID-19 has stimulated innovation and collaboration on an unprecedented global scale. The COVID-19 Knowledge Accelerator (COKA) Initiative is an international volunteer organization with over a hundred participants and 11 active working groups advancing standards, systems, terminologies, metadata frameworks, tools, and demonstration projects for computable expression of biomedical knowledge. COKA is an evolution of the Fast Healthcare Interoperability Resources (FHIR®) for Evidence Based Medicine (EBM) Knowledge Assets (aka EBMonFHIR) project. These organizations are working to find solutions for the current inefficiencies in the scientific dissemination systems we use today. Using structured (computable) results data directly from research and research publications will greatly accelerate evidence synthesis by reducing redundant efforts and enhancing interoperability. A panel of COKA leaders with diverse clinical informatics experience and research endeavors will share their most recent accomplishments and challenges. Participants will learn what it takes to make science computable and how to participate in the COKA initiative.